Treatment of MIBC
Treatment of MIBC
The treatment of MIBC is complex and includes the removal of tumour tissue while limiting disease progression and the development of metastases.1–4
Radical cystectomy involves the complete removal of the bladder and represents the current standard of care for MIBC.1,3,4
Radiation therapy can be used as an alternative to surgery or in combination with chemotherapy with the aim to shrink the tumour.2–4
Cisplatin-based chemotherapy
- Neoadjuvant chemotherapy may be used before surgery to shrink the tumour, making it easier to remove, and reducing the risk of metastases5–7
- Adjuvant chemotherapy may be given after surgery to reduce the risk of micro-metastases and disease recurrence5,6
- Perioperative chemotherapy is chemotherapy given both before and after surgery to shrink the tumour and reduce the risk of post-operative disease recurrence7
Chemoradiotherapy combines radiation therapy and chemotherapy to shrink the tumour and reduce the risk of disease recurrence and metastases.2–4
Bladder preservation techniques may be used and can include trans-uretheral resection (TURBT), chemotherapy and radiation.2–4
Immunotherapy may be used in the adjuvant setting to enhance the anti-tumour immune response.2–4
